Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00475247" target="_blank" >RIV/61388971:_____/17:00475247 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bcp.2016.12.001" target="_blank" >http://dx.doi.org/10.1016/j.bcp.2016.12.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bcp.2016.12.001" target="_blank" >10.1016/j.bcp.2016.12.001</a>

Result language

angličtina

Original language name

Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications

Original language description

Lincomycin and its derivatives are antibiotics exhibiting biological activity against bacteria, especially Gram-positive ones, and also protozoans. Lincomycin and its semi-synthetic chlorinated derivative clindamycin are widely used in clinical practice. Both antibiotics are bacteriostatic, inhibiting protein synthesis in sensitive bacteria, however, at higher concentrations, they may be bactericidal. Clindamycin is usually much more active than lincomycin in the treatment of bacterial infections, in particular those caused by anaerobic species, it can also be used for the treatment of important protozoal diseases, e.g. malaria, most effectively in combination with other antibiotic or non-antibiotic antimicrobials (primaquine, fosfidomycin, benzoyl peroxide). Chemical structures of lincosamide antibiotics and the biosynthesis of lincomycin and its genetic control have been summarized and described. Resistance to lincomycin and clindamycin may be caused by methylation of 23S ribosomal RNA, modification of the antibiotics by specific enzymes or active efflux from the bacterial cell.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Pharmacology

ISSN

0006-2952

e-ISSN

—

Volume of the periodical

133

Issue of the periodical within the volume

June 1 SI

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

20-28

UT code for WoS article

000401684500003

EID of the result in the Scopus database

2-s2.0-85007575129