Polydatin and its derivatives inhibit fatty acid desaturases in microorganisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00475876" target="_blank" >RIV/61388971:_____/17:00475876 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/17:10360617 RIV/60461373:22330/17:43901987

Result on the web

<a href="http://dx.doi.org/10.1002/ejlt.201600369" target="_blank" >http://dx.doi.org/10.1002/ejlt.201600369</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejlt.201600369" target="_blank" >10.1002/ejlt.201600369</a>

Result language

angličtina

Original language name

Polydatin and its derivatives inhibit fatty acid desaturases in microorganisms

Original language description

Antioxidant plant polyphenols resveratrol and its glycoside polydatin at 500g/L were found to have two distinct effects on yeasts and algae depending on the cell content of polyunsaturated fatty acids (PUFA). In yeasts that do not produce PUFA, resveratrol (0.5mg/L) increased resistance to biosynthesized ethanol (an important property in winemaking) to 22% EtOH in Saccharomyces cerevisiae and 14% EtOH in Torulaspora delbruckii, the fatty acid content being changed only slightly, whereas in the PUFA-producing algae Desmodesmus quadricauda and Euglena gracilis both compounds act as inhibitors of 4 desaturases blocking the formation of both even- and odd-numbered PUFA having the first double-bond in position 4. This leads to the biotechnologically desirable accumulation of the health-beneficial polyunsaturated fatty acids (PUFAs), docosapentaenoic (DPA), and docosahexaenoic acid (DHA). Practical applications: Employing natural stilbene compounds has far-reaching use in biotechnological applications such as the production of ethanol used for biofuels or production of wine and beer. It allows the production of beer with higher alcohol content, without resorting to the use of consumer-unacceptable genetically modified yeast. In brewing, when the yeast is often repeatedly reused to ferment fresh wort, higher resistance of yeast in the presence of these compounds can lead to an increase in the number of yeast reuses and thereby reduce economic costs of the brewery needed for preparation of inocula. Using polydatin as inhibitor of 4 desaturase in Euglena and Desmodesmus algae blocks the biosynthesis of both even- and odd-numbered PUFAs having a double bond in position 4. This leads to a change in the content of fatty acids and accumulation of biosynthetic precursors, e.g., 22:5n-3 acid that has more favorable pharmacological effects than docosahexaenoic acid (22:6n-3) Natural stilbenes such as polydatin and resveratrol have not yet been known as inhibitors of desaturases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Lipid Science and Technology

ISSN

1438-7697

e-ISSN

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Volume of the periodical

119

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000402962200015

EID of the result in the Scopus database

2-s2.0-85013455565