Significance of long chain polyunsaturated fatty acids in human health

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00477900" target="_blank" >RIV/61388971:_____/17:00477900 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s40169-017-0153-6" target="_blank" >http://dx.doi.org/10.1186/s40169-017-0153-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40169-017-0153-6" target="_blank" >10.1186/s40169-017-0153-6</a>

Result language

angličtina

Original language name

Significance of long chain polyunsaturated fatty acids in human health

Original language description

In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators. In this sense, new families of PUFA-derived lipid mediators, including resolvins derived from EPA and DHA, and protectins and maresins derived from DHA, are being increasingly investigated because of their active role in the 'return to homeostasis' process and resolution of inflammation. Recent findings reviewed in the present study highlight that the omega-6 fatty acid ARA appears increased, and omega-3 EPA and DHA decreased in most cancer tissues compared to normal ones, and that increments in omega-3 LC-PUFAs consumption and an omega-6/omega-3 ratio of 2-4:1, are associated with a reduced risk of breast, prostate, colon and renal cancers. Along with their lipid-lowering properties, omega-3 LC-PUFAs also exert cardioprotective functions, such as reducing platelet aggregation and inflammation, and controlling the presence of DHA in our body, especially in our liver and brain, which is crucial for optimal brain functionality. Considering that DHA is the principal omega-3 FA in cortical gray matter, the importance of DHA intake and its derived lipid mediators have been recently reported in patients with major depressive and bipolar disorders, Alzheimer disease, Parkinson's disease, and amyotrophic lateral sclerosis. The present study reviews the relationships between major diseases occurring today in the Western world and LC-PUFAs.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/LO1416" target="_blank" >LO1416: Algatech plus</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CLINICAL AND TRANSLATIONAL MEDICINE

ISSN

2001-1326

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

JUL 27

Country of publishing house

GB - UNITED KINGDOM

Number of pages

19

Pages from-to

—

UT code for WoS article

000406662300001

EID of the result in the Scopus database

—