Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00482104" target="_blank" >RIV/61388971:_____/17:00482104 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/17:00480103 RIV/00216208:11310/17:10372876 RIV/00023001:_____/17:00075976
Result on the web
<a href="http://dx.doi.org/10.3748/wjg.v23.i25.4548" target="_blank" >http://dx.doi.org/10.3748/wjg.v23.i25.4548</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v23.i25.4548" target="_blank" >10.3748/wjg.v23.i25.4548</a>
Alternative languages
Result language
angličtina
Original language name
Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis
Original language description
AIM nTo characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). nnMETHODS nStool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with (n = 32) or without (n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16S ribosomal RNA gene were sequenced on Illumina MiSeq platform to cover low taxonomic levels. Data were further processed in QIIME employing MaAsLin and LEfSe tools for analysis of the output data. nnRESULTS nMicrobial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease (IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales. nnCONCLUSION nPSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes (PSC-IBD and UC).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NV15-28064A" target="_blank" >NV15-28064A: Immunological biomarkers for noninvasive diagnosis, outcome prediction and therapy selection in inflammatory bowel disease</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Gastroenterology
ISSN
1007-9327
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
25
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
4548-4558
UT code for WoS article
000405228900009
EID of the result in the Scopus database
2-s2.0-85023161547