Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00482796" target="_blank" >RIV/61388971:_____/17:00482796 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/17:00482796

Result on the web

<a href="http://dx.doi.org/10.1080/1061186X.2017.1358724" target="_blank" >http://dx.doi.org/10.1080/1061186X.2017.1358724</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1061186X.2017.1358724" target="_blank" >10.1080/1061186X.2017.1358724</a>

Result language

angličtina

Original language name

Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics

Original language description

Polymer carriers based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers with incorporated organic nitrates as nitric oxide (NO) donors were designed with the aim to localise NO generation in solid tumours, thus highly increasing the enhanced permeability and retention (EPR) effect. The NO donors were coupled to the polymer carrier either through a stable bond or through a hydrolytically degradable, pH sensitive, bond. In vivo, the co-administration of the polymer NO donor and HPMA copolymer-bound cytotoxic drug (doxorubicin, Dox) resulted in an improvement in the treatment of murine EL4 T-cell lymphoma. The polymer NO donors neither potentiated the in vitro toxicity of the cytotoxic drug nor exerted any effect on in vivo model without the EPR effect, such as BCL1 leukaemia. Thus, an increase in passive accumulation of the nanomedicine carrying cytotoxic drug via NO-enhanced EPR effect was the operative mechanism of action. The most significant improvement in the therapy was observed in a combination treatment with such a polymer conjugate of Dox, which is characterised by increased circulation in the blood and efficient accumulation in solid tumours. Notably, the combination treatment enabled the development of an anti-tumour immune response, which was previously demonstrated as an important feature of HPMA-based polymer cytotoxic drugs.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Drug Targeting

ISSN

1061-186X

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

9-10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

796-808

UT code for WoS article

000415813900006

EID of the result in the Scopus database

2-s2.0-85027030147