Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00482857" target="_blank" >RIV/61388971:_____/17:00482857 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/nar/gkx805" target="_blank" >http://dx.doi.org/10.1093/nar/gkx805</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gkx805" target="_blank" >10.1093/nar/gkx805</a>

Result language

angličtina

Original language name

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

Original language description

Protein synthesis is mediated via numerous molecules including the ribosome, mRNA, tRNAs, as well as translation initiation, elongation and release factors. Some of these factors play several roles throughout the entire process to ensure proper assembly of the preinitiation complex on the right mRNA, accurate selection of the initiation codon, errorless production of the encoded polypeptide and its proper termination. Perhaps, the most intriguing of these multitasking factors is the eukaryotic initiation factor eIF3. Recent evidence strongly suggests that this factor, which coordinates the progress of most of the initiation steps, does not come off the initiation complex upon subunit joining, but instead it remains bound to 80S ribosomes and gradually falls off during the first few elongation cycles to: (1) promote resumption of scanning on the same mRNA molecule for reinitiation downstream-in case of translation of upstream ORFs short enough to preserve eIF3 bound, or (2) come back during termination on long ORFs to fine tune its fidelity or, if signaled, promote programmed stop codon readthrough. Here, we unite recent structural views of the eIF3-40S complex and discus all known eIF3 roles to provide a broad picture of the eIF3' s impact on translational control in eukaryotic cells.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/GA17-06238S" target="_blank" >GA17-06238S: In-depth analysis of the function and regulatory potential of individual subunits of human translation initiation factor 3 and their subcomplexes.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

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Volume of the periodical

45

Issue of the periodical within the volume

19

Country of publishing house

GB - UNITED KINGDOM

Number of pages

21

Pages from-to

10948-10968

UT code for WoS article

000414552300008

EID of the result in the Scopus database

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