Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00484574" target="_blank" >RIV/61388971:_____/17:00484574 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/cddiscovery.2017.16" target="_blank" >http://dx.doi.org/10.1038/cddiscovery.2017.16</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/cddiscovery.2017.16" target="_blank" >10.1038/cddiscovery.2017.16</a>

Result language

angličtina

Original language name

Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets

Original language description

In recent years it turned out that there is not only extensive communication between the nucleus and mitochondria but also between mitochondria and lipid droplets (LDs) as well. We were able to demonstrate that a number of proteins shuttle between LDs and mitochondria and it depends on the metabolic state of the cell on which organelle these proteins are predominantly localized. Responsible for the localization of the particular proteins is a protein domain consisting of two alfa-helices, which we termed V-domain according to the predicted structure. So far we have detected this domain in the following proteins: mammalian BAX, BCL-XL, TCTP and yeast Mmi1p and Erg6p. According to our experiments there are two functions of this domain: (1) shuttling of proteins to mitochondria in times of stress and apoptosis, (2) clearing the outer mitochondrial membrane from pro- as well as anti-apoptotic proteins by moving them to LDs after the stress ceases. In this way the LDs are used by the cell to modulate stress response.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Death Discovery

ISSN

2058-7716

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

March 20

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

17016

UT code for WoS article

000463082900029

EID of the result in the Scopus database

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