Teicoplanin resistance in Staphylococcus haemolyticus is associated with mutations in histidine kinases VraS and WalK
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00488776" target="_blank" >RIV/61388971:_____/18:00488776 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.diagmicrobio.2017.11.007" target="_blank" >http://dx.doi.org/10.1016/j.diagmicrobio.2017.11.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.diagmicrobio.2017.11.007" target="_blank" >10.1016/j.diagmicrobio.2017.11.007</a>
Alternative languages
Result language
angličtina
Original language name
Teicoplanin resistance in Staphylococcus haemolyticus is associated with mutations in histidine kinases VraS and WalK
Original language description
We investigated the genetic basis of glycopeptide resistance in laboratory-derived strains of S. haemolyticus with emphasis on differences between vancomycin and teicoplanin. The genomes of two stable teicoplanin-resistant laboratory mutants selected on vancomycin or teicoplanin were sequenced and compared to parental S. haemolyticus strain W2/124. Only the two non-synonymous mutations, VraS Q289K and Walk V550 L were identified. No other mutations or genome rearrangements were detected. Increased cell wall thickness, resistance to lysostaphin-induced lysis and adaptation of cell growth rates specifically to teicoplanin were phenotypes observed in a sequenced strain with the VraS Q289K mutation. Neither of the VraS Q289K and Wall< V550 L mutations was present in the genomes of 121 S. haemolyticus clinical isolates. However, all but two of the teicoplanin resistant strains carried non-synonymous SNP5 in vraSRTU and walKR-YycHIJ operons pointing to their importance for the glycopeptide resistance. (C) 2017 Elsevier Inc. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diagnostic Microbiology and Infectious Disease
ISSN
0732-8893
e-ISSN
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Volume of the periodical
90
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
233-240
UT code for WoS article
000426228700015
EID of the result in the Scopus database
2-s2.0-85037725101