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Teicoplanin resistance in Staphylococcus haemolyticus is associated with mutations in histidine kinases VraS and WalK

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00488776" target="_blank" >RIV/61388971:_____/18:00488776 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.diagmicrobio.2017.11.007" target="_blank" >http://dx.doi.org/10.1016/j.diagmicrobio.2017.11.007</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.diagmicrobio.2017.11.007" target="_blank" >10.1016/j.diagmicrobio.2017.11.007</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Teicoplanin resistance in Staphylococcus haemolyticus is associated with mutations in histidine kinases VraS and WalK

  • Original language description

    We investigated the genetic basis of glycopeptide resistance in laboratory-derived strains of S. haemolyticus with emphasis on differences between vancomycin and teicoplanin. The genomes of two stable teicoplanin-resistant laboratory mutants selected on vancomycin or teicoplanin were sequenced and compared to parental S. haemolyticus strain W2/124. Only the two non-synonymous mutations, VraS Q289K and Walk V550 L were identified. No other mutations or genome rearrangements were detected. Increased cell wall thickness, resistance to lysostaphin-induced lysis and adaptation of cell growth rates specifically to teicoplanin were phenotypes observed in a sequenced strain with the VraS Q289K mutation. Neither of the VraS Q289K and Wall< V550 L mutations was present in the genomes of 121 S. haemolyticus clinical isolates. However, all but two of the teicoplanin resistant strains carried non-synonymous SNP5 in vraSRTU and walKR-YycHIJ operons pointing to their importance for the glycopeptide resistance. (C) 2017 Elsevier Inc. All rights reserved.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Diagnostic Microbiology and Infectious Disease

  • ISSN

    0732-8893

  • e-ISSN

  • Volume of the periodical

    90

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    233-240

  • UT code for WoS article

    000426228700015

  • EID of the result in the Scopus database

    2-s2.0-85037725101