Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00490082" target="_blank" >RIV/61388971:_____/18:00490082 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fmicb.2018.00774" target="_blank" >http://dx.doi.org/10.3389/fmicb.2018.00774</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmicb.2018.00774" target="_blank" >10.3389/fmicb.2018.00774</a>
Alternative languages
Result language
angličtina
Original language name
Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Original language description
Host's physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels. A few obligate anaerobic strains inhabiting the oral cavity are involved in the pathogenesis of oral diseases. Interestingly, these microbiota components are also enriched in gut inflammatory and tumor tissue. An altered microbiota composition - dysbiosis - and formation of polymicrobial biofilms seem to play important roles in the development of oral diseases and colorectal cancer. In this review, we describe the differences in composition of commensal microbiota in the oral cavity and large intestine and the mechanisms by which microbiota affect the inflammatory and carcinogenic response of the host.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Microbiology
ISSN
1664-302X
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
APR 20
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
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UT code for WoS article
000430492500001
EID of the result in the Scopus database
2-s2.0-85045753928