The emerging connections between IGF1, the intestinal microbiome, Lactobacillus strains and bone growth

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00492016" target="_blank" >RIV/61388971:_____/18:00492016 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1530/JME-17-0292" target="_blank" >http://dx.doi.org/10.1530/JME-17-0292</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/JME-17-0292" target="_blank" >10.1530/JME-17-0292</a>

Result language
angličtina
Original language name
The emerging connections between IGF1, the intestinal microbiome, Lactobacillus strains and bone growth
Original language description
In most animal species, postnatal growth is controlled by conserved insulin/insulinlike growth factor (IGF) signaling. In mammals, juvenile growth is characterized by a longitudinal bone growth resulting from the ossification of the growth plate. This ossification is under IGF1 influence through endocrine and paracrine mechanisms. Moreover, the nutritional status has been largely described as an important factor influencing the insulin/insulin-like growth factor signaling. It is now well established that the gut microbiota modulates the nutrient availability of its host. Hence, studies of the interaction between nutritional status, gut microbiota and bone growth have recently emerged. Here, we review recent findings using experimental models about the impact of gut bacteria on the somatotropic axis and its consequence on the bone growth. We also discuss the perspectives of these studies in opening an entire field for clinical interventions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)

Project
<a href="/en/project/GJ18-07015Y" target="_blank" >GJ18-07015Y: Dissecting the role of microbiota and specific bacterial strains in mouse juvenile growth under normal/poor nutritional conditions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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