Comparative genomics of Czech vaccine strains of Bordetella pertussis.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00497620" target="_blank" >RIV/61388971:_____/18:00497620 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/femspd/fty071" target="_blank" >http://dx.doi.org/10.1093/femspd/fty071</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/femspd/fty071" target="_blank" >10.1093/femspd/fty071</a>
Alternative languages
Result language
angličtina
Original language name
Comparative genomics of Czech vaccine strains of Bordetella pertussis.
Original language description
Bordetella pertussis is a strictly human pathogen causing the respiratory infectious disease called whooping cough or pertussis. B. pertussis adaptation to acellular pertussis vaccine pressure has been repeatedly highlighted, but recent data indicate that adaptation of circulating strains started already in the era of the whole cell pertussis vaccine (wP) use. We sequenced the genomes of five B. pertussis wP vaccine strains isolated in the former Czechoslovakia in the pre-wP (1954–1957) and early wP (1958–1965) eras, when only limited population travel into and out of the country was possible. Four isolates exhibit a similar genome organization and form a distinct phylogenetic cluster with a geographic signature. The fifth strain is rather distinct, both in genome organization and SNP-based phylogeny. Surprisingly, despite isolation of this strain before 1966, its closest sequenced relative appears to be a recent isolate from the US. On the genome content level, the five vaccine strains contained both new and already described regions of difference. One of the new regions contains duplicated genes potentially associated with transport across the membrane. The prevalence of this region in recent isolates indicates that its spread might be associated with selective advantage leading to increased strain fitness.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NV16-30782A" target="_blank" >NV16-30782A: Translation Omics technologies into better understanding of Bordetella pertussis pathogenicity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pathogens and Disease
ISSN
2049-632X
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
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UT code for WoS article
000453675500004
EID of the result in the Scopus database
2-s2.0-85061853892