Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00503986" target="_blank" >RIV/61388971:_____/19:00503986 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/19:73594102 RIV/61989592:15310/19:73594102 RIV/00098892:_____/19:N0000022

Result on the web

<a href="https://www.mdpi.com/1420-3049/24/1/61" target="_blank" >https://www.mdpi.com/1420-3049/24/1/61</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24010061" target="_blank" >10.3390/molecules24010061</a>

Result language

angličtina

Original language name

Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study

Original language description

Silymarin is a well-known standardized extract from the seeds of milk thistle (Silybum marianum L., Asteraceae) with a pleiotropic effect on human health, including skin anticancer potential. Detailed characterization of flavonolignans properties affecting interactions with human skin was of interest. The partition coefficients log P-ow of main constitutive flavonolignans, taxifolin and their respective dehydro derivatives were determined by a High Performance Liquid Chromatography (HPLC) method and by mathematical (in silico) approaches in n-octanol/water and model lipid membranes. These parameters were compared with human skin intake ex vivo. The experimental log P-ow values for individual diastereomers were estimated for the first time. The replacement of n-octanol with model lipid membranes in the theoretical lipophilicity estimation improved the prediction strength. During transdermal transport, all the studied compounds permeated the human skin ex vivo, none of them reached the acceptor liquid. Both experimental/theoretical tools allowed the studied polyphenols to be divided into two groups: low (taxifolin, silychristin, silydianin) vs. high (silybin, dehydrosilybin, isosilybin) lipophilicity and skin intake. In silico predictions can be usefully applied for estimating general lipophilicity trends, such as skin penetration or accumulation predictions. However, the theoretical models cannot yet provide the dermal delivery differences of compounds with very similar physico-chemical properties, e.g., between diastereomers.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30107 - Medicinal chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

61

UT code for WoS article

000457150200061

EID of the result in the Scopus database

2-s2.0-85059244691