The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00504737" target="_blank" >RIV/61388971:_____/19:00504737 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/19:10394211 RIV/00064203:_____/19:10394211 RIV/68378041:_____/19:00579581
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210797" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210797</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0210797" target="_blank" >10.1371/journal.pone.0210797</a>
Alternative languages
Result language
angličtina
Original language name
The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis
Original language description
Background/Purpose nWe analyzed the capacity of urinary Intestinal fatty acid-binding protein (I-FABP) to quantify the degree of mucosal injury in neonates with gastroschisis (GS) and to predict the speed of their clinical recovery after surgery. nMethods nIn this prospective study, we collected urine during the first 48h after surgery from neonates operated between 2012 and 2015 for GS. Neonates with surgery that did not include gut mucosa served as controls for simple GS and neonates with surgery for intestinal atresia served as control for complex GS patients. The I-FABP levels were analyzed by ELISA. nResults nUrinary I-FABP after the surgery is significantly higher in GS newborns than in control group, I-FABP in complex GS is higher than in simple GS. I-FABP can predict subsequent operation for ileus in patients with complex GS. Both ways of abdominal wall closure (i.e. primary closure and stepwise reconstruction) led to similar levels of I-FABP. None of the static I-FABP values was useful for the outcome prediction. The steep decrease in I-FABP after the surgery is associated with faster recovery, but it cannot predict early start of minimal enteral feeding, full enteral feeding or length of hospitalization. nConclusion nUrinary I-FABP reflects the mucosal damage in gastroschisis but it has only a limited predictive value for patients' outcome.nn
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NV15-28064A" target="_blank" >NV15-28064A: Immunological biomarkers for noninvasive diagnosis, outcome prediction and therapy selection in inflammatory bowel disease</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
—
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
e0210797
UT code for WoS article
000455808000049
EID of the result in the Scopus database
2-s2.0-85059963050