The role of gut microbiota in intestinal and liver diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00507943" target="_blank" >RIV/61388971:_____/19:00507943 - isvavai.cz</a>
Result on the web
<a href="https://journals.sagepub.com/doi/10.1177/0023677218818605" target="_blank" >https://journals.sagepub.com/doi/10.1177/0023677218818605</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0023677218818605" target="_blank" >10.1177/0023677218818605</a>
Alternative languages
Result language
angličtina
Original language name
The role of gut microbiota in intestinal and liver diseases
Original language description
The world-wide incidence of many immune-mediated and metabolic diseases, including those of the intestines and liver, is steadily increasing. Gut microbiota plays a central role in the pathogenesis of these diseases as it mediates environmental changes to the intestinal immune system. Various environmental factors including diet, food additives and medication also trigger the compositional and functional alterations of microbiota, that is, dysbiosis, and this dysbiosis is closely associated with many chronic inflammatory diseases. However, the causal relationship remains unclear for the majority of these diseases. In this review, we discuss essential epidemiological data, known pathogenetic factors including those of genetic and environmental nature, while mainly focusing on the role of gut microbiota in the development of selected intestinal and liver diseases. Using specific examples, we also briefly describe some of the most widely-used animal models including gnotobiotic models and their contribution to the research of pathogenetic mechanisms of the host-microbiota relationship.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Laboratory Animals
ISSN
0023-6772
e-ISSN
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Volume of the periodical
53
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
271-280
UT code for WoS article
000469385000006
EID of the result in the Scopus database
2-s2.0-85067175217