Reductant-Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00508991" target="_blank" >RIV/61388971:_____/19:00508991 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/19:00508991 RIV/00216208:11310/19:10416651
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201902944" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201902944</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201902944" target="_blank" >10.1002/chem.201902944</a>
Alternative languages
Result language
angličtina
Original language name
Reductant-Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins
Original language description
A series of fluoroalkylated cyclic lambda3-iodanes and their hydrochloride salts was prepared and used in a combination with sodium ascorbate in buffer or aqueous methanol mixtures for radical fluoroalkylation of a range of substituted indoles, pyrroles, tryptophan or its derivatives, and Trp residues in peptides. As demonstrated on several peptides, aromatic amino acid residues Trp, Tyr, Phe and His are targeted with high selectivity to Trp. The functionalization method is biocompatible, mild, rapid and transition metal-free. Proteins myoglobin, ubiquitin and human carbonic anhydrase I were also successfully functionalized.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
69
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
15779-15785
UT code for WoS article
000493155200001
EID of the result in the Scopus database
2-s2.0-85074599284