IN VIVO BIODOSIMETRY OF PORCINE T-LYMPHOCYTE SUBSETS AND NK CELLS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00524744" target="_blank" >RIV/61388971:_____/20:00524744 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/19:00537270
Result on the web
<a href="https://academic.oup.com/rpd/article-abstract/186/2-3/181/5704036" target="_blank" >https://academic.oup.com/rpd/article-abstract/186/2-3/181/5704036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/rpd/ncz199" target="_blank" >10.1093/rpd/ncz199</a>
Alternative languages
Result language
angličtina
Original language name
IN VIVO BIODOSIMETRY OF PORCINE T-LYMPHOCYTE SUBSETS AND NK CELLS
Original language description
The aim of the present study was to evaluate the biodosimetric potential of peripheral blood lymphocytes, particularly of T-cell subsets (null and T helper) and natural killer cells (NK), upon exposure to gamma irradiation (Co-60) in vivo. For this purpose, the change in relative numbers of NK cells and T-lymphocyte subsets, as well as in the H2AX phosphorylation rate, were evaluated as potential early markers of the lymphocytic response to irradiation in vivo. These experiments were performed on a Large White Pig model. As a result, significant but not dose-dependent changes in the proportion of lymphocyte subpopulations (NK cells, null and T helper cells) were found after exposure to ionising radiation in vivo. On the other hand, circulating NK cells showed relatively higher radioresistance capacity when compared to the T-lymphocyte subsets, however, gamma-H2AX expression showed no significant difference between the evaluated lymphocyte subsets.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiation Protection Dosimetry
ISSN
0144-8420
e-ISSN
—
Volume of the periodical
186
Issue of the periodical within the volume
2-3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
181-185
UT code for WoS article
000530582200008
EID of the result in the Scopus database
2-s2.0-85082780217