Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00525185" target="_blank" >RIV/61388971:_____/20:00525185 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/20:00525185 RIV/00216208:11110/20:10407121 RIV/00216208:11160/20:10407121 RIV/00216208:11310/20:10407121 and 2 more
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14922" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14922</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcmm.14922" target="_blank" >10.1111/jcmm.14922</a>
Alternative languages
Result language
angličtina
Original language name
Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer
Original language description
Arthrospira platensis, a blue-green alga, is a popular nutraceutical substance having potent antioxidant properties with potential anti-carcinogenic activities. The aim of our study was to assess the possible anti-angiogenic effects of A platensis in an experimental model of pancreatic cancer. The effects of an A platensis extract were investigated on human pancreatic cancer cells (PA-TU-8902) and immortalized endothelial-like cells (Ea.hy926). PA-TU-8902 pancreatic tumours xenografted to athymic mice were also examined. In vitro migration and invasiveness assays were performed on the tested cells. Multiple angiogenic factors and signalling pathways were analysed in the epithelial, endothelial and cancer cells, and tumour tissue. The A platensis extract exerted inhibitory effects on both migration and invasion of pancreatic cancer as well as endothelial-like cells. Tumours of mice treated with A platensis exhibited much lesser degrees of vascularization as measured by CD31 immunostaining (P = .004). Surprisingly, the VEGF-A mRNA and protein expressions were up-regulated in pancreatic cancer cells. A platensis inhibited ERK activation upstream of Raf and suppressed the expression of ERK-regulated proteins. Treatment of pancreatic cancer with A platensis was associated with suppressive effects on migration and invasiveness with various anti-angiogenic features, which might account for the anticancer effects of this blue-green alga.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV16-29032A" target="_blank" >NV16-29032A: ERK pathway activation as a prognostic tool and a prospective therapeutic target in head and neck squamous cell carcinoma and malignant melanoma</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
2402-2415
UT code for WoS article
000507858400001
EID of the result in the Scopus database
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