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Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00525185" target="_blank" >RIV/61388971:_____/20:00525185 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378050:_____/20:00525185 RIV/00216208:11110/20:10407121 RIV/00216208:11160/20:10407121 RIV/00216208:11310/20:10407121 and 2 more

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14922" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14922</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/jcmm.14922" target="_blank" >10.1111/jcmm.14922</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer

  • Original language description

    Arthrospira platensis, a blue-green alga, is a popular nutraceutical substance having potent antioxidant properties with potential anti-carcinogenic activities. The aim of our study was to assess the possible anti-angiogenic effects of A platensis in an experimental model of pancreatic cancer. The effects of an A platensis extract were investigated on human pancreatic cancer cells (PA-TU-8902) and immortalized endothelial-like cells (Ea.hy926). PA-TU-8902 pancreatic tumours xenografted to athymic mice were also examined. In vitro migration and invasiveness assays were performed on the tested cells. Multiple angiogenic factors and signalling pathways were analysed in the epithelial, endothelial and cancer cells, and tumour tissue. The A platensis extract exerted inhibitory effects on both migration and invasion of pancreatic cancer as well as endothelial-like cells. Tumours of mice treated with A platensis exhibited much lesser degrees of vascularization as measured by CD31 immunostaining (P = .004). Surprisingly, the VEGF-A mRNA and protein expressions were up-regulated in pancreatic cancer cells. A platensis inhibited ERK activation upstream of Raf and suppressed the expression of ERK-regulated proteins. Treatment of pancreatic cancer with A platensis was associated with suppressive effects on migration and invasiveness with various anti-angiogenic features, which might account for the anticancer effects of this blue-green alga.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/NV16-29032A" target="_blank" >NV16-29032A: ERK pathway activation as a prognostic tool and a prospective therapeutic target in head and neck squamous cell carcinoma and malignant melanoma</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Cellular and Molecular Medicine

  • ISSN

    1582-1838

  • e-ISSN

  • Volume of the periodical

    24

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    2402-2415

  • UT code for WoS article

    000507858400001

  • EID of the result in the Scopus database