Rhizoferrin Glycosylation in Rhizopus microsporus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00531142" target="_blank" >RIV/61388971:_____/20:00531142 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/20:10412707 RIV/61989592:15310/20:73604133 RIV/00064203:_____/20:10412707 RIV/71009396:_____/20:N0000003
Result on the web
<a href="https://www.mdpi.com/2309-608X/6/2/89" target="_blank" >https://www.mdpi.com/2309-608X/6/2/89</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jof6020089" target="_blank" >10.3390/jof6020089</a>
Alternative languages
Result language
angličtina
Original language name
Rhizoferrin Glycosylation in Rhizopus microsporus
Original language description
Rhizopus spp. are the most common etiological agents of mucormycosis, causing over 90% mortality in disseminated infections. The diagnosis relies on histopathology, culture, and/or polymerase chain reaction. For the first time, the glycosylation of rhizoferrin (RHF) was described in a Rhizopus microsporus clinical isolate by liquid chromatography and accurate tandem mass spectrometry. The fermentation broth lyophilizate contained 345.3 ± 13.5, 1.2 ± 0.03, and 0.03 ± 0.002 mg/g of RHF, imido-RHF, and bis-imido-RHF, respectively. Despite a considerable RHF secretion rate, we did not obtain conclusive RHF detection from a patient with disseminated mucormycosis caused by the same R. microsporus strain. We hypothesize that parallel antimycotic therapy, RHF biotransformation, and metabolism compromised the analysis. On the other hand, the full profile of posaconazole metabolites was retrieved by our in house software CycloBranch.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Fungi
ISSN
2309-608X
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
89
UT code for WoS article
000551257800022
EID of the result in the Scopus database
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