The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00531243" target="_blank" >RIV/61388971:_____/20:00531243 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/20:00531243 RIV/61989592:15110/20:73605132
Result on the web
<a href="https://www.nature.com/articles/s41598-020-65595-9" target="_blank" >https://www.nature.com/articles/s41598-020-65595-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-65595-9" target="_blank" >10.1038/s41598-020-65595-9</a>

Result language
angličtina
Original language name
The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice
Original language description
The gut microbiota is involved in a number of different metabolic processes of the host organism, including the metabolism of xenobiotics. In our study, we focused on liver cytochromes P450 (CYPs), which can metabolize a wide range of exo- and endogenous molecules. We studied changes in mRNA expression and CYP enzyme activities, as well as the mRNA expression of transcription factors that have an important role in CYP expression, all in stressed germ-free (GF) and stressed specific-pathogen-free (SPF) mice. Besides the presence of the gut microbiota, we looked at the difference between acute and chronic stress. Our results show that stress has an impact on CYP mRNA expression, but it is mainly chronic stress that has a significant effect on enzyme activities along with the gut microbiome. In acutely stressed mice, we observed significant changes at the mRNA level, however, the corresponding enzyme activities were not influenced. Our study suggests an important role of the gut microbiota along with chronic psychosocial stress in the expression and activity of CYPs, which can potentially lead to less effective drug metabolism and, as a result, a harmful impact on the organism.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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