The Oral Microbiome in Periodontal Health

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542109" target="_blank" >RIV/61388971:_____/21:00542109 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10427683 RIV/00064165:_____/21:10427683 RIV/00216208:11310/21:10427683

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fcimb.2021.629723/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcimb.2021.629723/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcimb.2021.629723" target="_blank" >10.3389/fcimb.2021.629723</a>

Result language

angličtina

Original language name

The Oral Microbiome in Periodontal Health

Original language description

The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained image of ´healthy OM´ can be distorted.To overcome this bias, we taxonomically characterized the OM in almost a hundred young students of dentistry with precise oral hygiene and no signs of periodontal disease. We compared the results with the OM composition of older periodontally healthy individuals and also a group of patients with severe periodontitis (aggressive periodontitis according to former classification system). The clustering analysis revealed not only two compact clearly separated clusters corresponding to each state of health, but also a group of samples forming an overlap between both well-pronounced states. Additionally, in the cluster of periodontally healthy samples, few outliers with atypical OM and two major stomatotypes could be distinguished, differing in the prevalence and relative abundance of two main bacterial genera: Streptococcus and Veillonella. We hypothesize that the two stomatotypes could represent the microbial succession from periodontal health to starting dysbiosis. The old and young periodontally healthy subjects do not cluster separately but a trend of the OM in older subjects to periodontitis is visible. Several bacterial genera were identified to be typically more abundant in older periodontally healthy subjects.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/NV17-30753A" target="_blank" >NV17-30753A: Use of parallel sequencing methods for monitoring of oral microbiome dynamics in the course of periodontal disease development and therapy.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Cellular and Infection Microbiology

ISSN

2235-2988

e-ISSN

2235-2988

Volume of the periodical

11

Issue of the periodical within the volume

MAR 22

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

629723

UT code for WoS article

000636669600001

EID of the result in the Scopus database

2-s2.0-85103649777