Current Aspects of the Role of Autoantibodies Directed Against Appetite-Regulating Hormones and the Gut Microbiome in Eating Disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542616" target="_blank" >RIV/61388971:_____/21:00542616 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/21:N0000025 RIV/00216208:11110/21:10428532 RIV/00064165:_____/21:10428532
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fendo.2021.613983/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FENDO_XXXXXXXX_auto-dlvrit" target="_blank" >https://www.frontiersin.org/articles/10.3389/fendo.2021.613983/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FENDO_XXXXXXXX_auto-dlvrit</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fendo.2021.613983" target="_blank" >10.3389/fendo.2021.613983</a>
Alternative languages
Result language
angličtina
Original language name
Current Aspects of the Role of Autoantibodies Directed Against Appetite-Regulating Hormones and the Gut Microbiome in Eating Disorders
Original language description
The equilibrium and reciprocal actions among appetite-stimulating (orexigenic) and appetite-suppressing (anorexigenic) signals synthesized in the gut, brain, microbiome and adipose tissue (AT), seems to play a pivotal role in the regulation of food intake and feeding behavior, anxiety, and depression. A dysregulation of mechanisms controlling the energy balance may result in eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). AN is a psychiatric disease defined by chronic self-induced extreme dietary restriction leading to an extremely low body weight and adiposity. BN is defined as out-of-control binge eating, which is compensated by self-induced vomiting, fasting, or excessive exercise. Certain gut microbiota-related compounds, like bacterial chaperone protein Escherichia coli caseinolytic protease B (ClpB) and food-derived antigens were recently described to trigger the production of autoantibodies cross-reacting with appetite-regulating hormones and neurotransmitters. Gut microbiome may be a potential manipulator for AT and energy homeostasis. Thus, the regulation of appetite, emotion, mood, and nutritional status is also under the control of neuroimmunoendocrine mechanisms by secretion of autoantibodies directed against neuropeptides, neuroactive metabolites, and peptides. In AN and BN, altered cholinergic, dopaminergic, adrenergic, and serotonergic relays may lead to abnormal AT, gut, and brain hormone secretion. The present review summarizes updated knowledge regarding the gut dysbiosis, gut-barrier permeability, short-chain fatty acids (SCFA), fecal microbial transplantation (FMT), blood-brain barrier permeability, and autoantibodies within the ghrelin and melanocortin systems in eating disorders. We expect that the new knowledge may be used for the development of a novel preventive and therapeutic approach for treatment of AN and BN.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NV17-28905A" target="_blank" >NV17-28905A: The Role of Gut Microbiome and Autoimmune Mechanisms in Patients with Anorexia Nervosa</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Endocrinology
ISSN
1664-2392
e-ISSN
1664-2392
Volume of the periodical
12
Issue of the periodical within the volume
APR 19 2021
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
613983
UT code for WoS article
000646314100001
EID of the result in the Scopus database
2-s2.0-85105244205