Local angiotensin-converting enzyme 2 gene expression in kidney allografts is not affected by renin-angiotensin-aldosterone inhibitors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542902" target="_blank" >RIV/61388971:_____/21:00542902 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/21:00081047
Result on the web
<a href="https://www.karger.com/Article/Abstract/513710" target="_blank" >https://www.karger.com/Article/Abstract/513710</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000513710" target="_blank" >10.1159/000513710</a>
Alternative languages
Result language
angličtina
Original language name
Local angiotensin-converting enzyme 2 gene expression in kidney allografts is not affected by renin-angiotensin-aldosterone inhibitors
Original language description
Background: Preclinical studies suggested that pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) by ACE inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) may increase local angiotensin-converting enzyme 2 (ACE2) expression. Methods: In this study, we evaluated the effect of ACEi or ARB treatment on expression of ACE2, ACE, and AGTR1 in 3-month protocol kidney allograft biopsies of stable patients using RT-qPCR (n = 48). Protein ACE2 expression was assessed using immunohistochemistry from paraffin sections. Results: The therapy with RAAS blockers was not associated with increased ACE2, ACE, or ATGR1 expression in kidney allografts and also ACE2 protein immunohistochemistry did not reveal differences among groups. Conclusions: ACEis or ARBs in kidney transplant recipients do not affect local ACE2 expression. This observation supports long-term RAAS treatment in kidney transplant recipients, despite acute complications such as COVID-19 where ACE2 serves as the entry protein for infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Kidney & Blood Pressure Research
ISSN
1420-4096
e-ISSN
1423-0143
Volume of the periodical
46
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
5
Pages from-to
245-249
UT code for WoS article
000632540000001
EID of the result in the Scopus database
2-s2.0-85103322183