Bacterial RTX toxins and host immunity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542933" target="_blank" >RIV/61388971:_____/21:00542933 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/co-infectiousdiseases/Abstract/2021/06000/Bacterial_RTX_toxins_and_host_immunity.3.aspx" target="_blank" >https://journals.lww.com/co-infectiousdiseases/Abstract/2021/06000/Bacterial_RTX_toxins_and_host_immunity.3.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/QCO.0000000000000726" target="_blank" >10.1097/QCO.0000000000000726</a>
Alternative languages
Result language
angličtina
Original language name
Bacterial RTX toxins and host immunity
Original language description
Purpose of review RTX toxin action often defines the outcome of bacterial infections. Here, we discuss the progress in understanding the impacts of RTX toxin activities on host immunity. Recent findings Bordetella pertussis CyaA activity paralyzes sentinel phagocytic cells by elevating cellular cAMP levels and blocks differentiation of infiltrating monocytes into bactericidal macrophages, promoting also de-differentiation of resident alveolar macrophages into monocyte-like cells. Vibrio cholerae multifunctional autoprocessing repeats-in-toxins (MARTX), through Rho inactivating and alpha/beta-hydrolase (ABH) domain action blocks mitogen-activated protein kinase signaling in epithelial cells and dampens the inflammatory responses of intestinal epithelia by blocking immune cell recruitment. The action of actin crosslinking effector domain and Ras/Rap1-specific endopeptidase (RRSP) domains of MARTX compromises the phagocytic ability of macrophages. Aggregatibacter actinomycetemcomitans LtxA action triggers neutrophil elastase release into periodontal tissue, compromising the epithelial barrier and promoting bacterial spreads into deeper tissue. Action of RTX toxins enables bacterial pathogens to cope with the fierce host immune defenses. RTX toxins often block phagocytosis and bactericidal reactive oxygen species and NO production. Some RTX toxins can reprogram the macrophages to less bactericidal cell types. Autophagy is hijacked for example by the activity of the V. cholerae ABH effector domain of the MARTX protein. Subversion of immune functions by RTX toxins thus promotes bacterial survival and proliferation in the host.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GX19-27630X" target="_blank" >GX19-27630X: Concerted toxin action in Bordetella pertussis virulence</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Infectious Diseases
ISSN
0951-7375
e-ISSN
1473-6527
Volume of the periodical
34
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
187-196
UT code for WoS article
000643796100002
EID of the result in the Scopus database
2-s2.0-85105904760