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Bacterial RTX toxins and host immunity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542933" target="_blank" >RIV/61388971:_____/21:00542933 - isvavai.cz</a>

  • Result on the web

    <a href="https://journals.lww.com/co-infectiousdiseases/Abstract/2021/06000/Bacterial_RTX_toxins_and_host_immunity.3.aspx" target="_blank" >https://journals.lww.com/co-infectiousdiseases/Abstract/2021/06000/Bacterial_RTX_toxins_and_host_immunity.3.aspx</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/QCO.0000000000000726" target="_blank" >10.1097/QCO.0000000000000726</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Bacterial RTX toxins and host immunity

  • Original language description

    Purpose of review RTX toxin action often defines the outcome of bacterial infections. Here, we discuss the progress in understanding the impacts of RTX toxin activities on host immunity. Recent findings Bordetella pertussis CyaA activity paralyzes sentinel phagocytic cells by elevating cellular cAMP levels and blocks differentiation of infiltrating monocytes into bactericidal macrophages, promoting also de-differentiation of resident alveolar macrophages into monocyte-like cells. Vibrio cholerae multifunctional autoprocessing repeats-in-toxins (MARTX), through Rho inactivating and alpha/beta-hydrolase (ABH) domain action blocks mitogen-activated protein kinase signaling in epithelial cells and dampens the inflammatory responses of intestinal epithelia by blocking immune cell recruitment. The action of actin crosslinking effector domain and Ras/Rap1-specific endopeptidase (RRSP) domains of MARTX compromises the phagocytic ability of macrophages. Aggregatibacter actinomycetemcomitans LtxA action triggers neutrophil elastase release into periodontal tissue, compromising the epithelial barrier and promoting bacterial spreads into deeper tissue. Action of RTX toxins enables bacterial pathogens to cope with the fierce host immune defenses. RTX toxins often block phagocytosis and bactericidal reactive oxygen species and NO production. Some RTX toxins can reprogram the macrophages to less bactericidal cell types. Autophagy is hijacked for example by the activity of the V. cholerae ABH effector domain of the MARTX protein. Subversion of immune functions by RTX toxins thus promotes bacterial survival and proliferation in the host.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    <a href="/en/project/GX19-27630X" target="_blank" >GX19-27630X: Concerted toxin action in Bordetella pertussis virulence</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Opinion in Infectious Diseases

  • ISSN

    0951-7375

  • e-ISSN

    1473-6527

  • Volume of the periodical

    34

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    187-196

  • UT code for WoS article

    000643796100002

  • EID of the result in the Scopus database

    2-s2.0-85105904760