Diclofenac Alters the Cell Cycle Progression of the Green Alga Chlamydomonas reinhardtii
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00546629" target="_blank" >RIV/61388971:_____/21:00546629 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2073-4409/10/8/1936" target="_blank" >https://www.mdpi.com/2073-4409/10/8/1936</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells10081936" target="_blank" >10.3390/cells10081936</a>
Alternative languages
Result language
angličtina
Original language name
Diclofenac Alters the Cell Cycle Progression of the Green Alga Chlamydomonas reinhardtii
Original language description
The aim of the study was to verify the hypothesis that a potential cause of the phytotoxicity of diclofenac (DCF, a non-steroidal anti-inflammatory drug) is an effect of cell cycle progression. This research was conducted using synchronous cultures of a model organism, green alga Chlamydomonas reinhardtii. The project examined DCF effects on selected parameters that characterize cell cycle progression, such as cell size, attainment of commitment points, DNA replication, number of nuclei formed during cells division and morphology of cells in consecutive stages of the cell cycle, together with the physiological and biochemical parameters of algae cells at different stages. We demonstrated that individual cell growth remained unaffected, whereas cell division was delayed in the DCF-treated groups grown in continuous light conditions, and the number of daughter cells from a single cell decreased. Thus, the cell cycle progression is a target affected by DCF, which has a similar anti-proliferative effect on mammalian cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GA19-12607S" target="_blank" >GA19-12607S: Growth and cell cycle - regulation of cell cycle entry and exit</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
10
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
1936
UT code for WoS article
000688980300001
EID of the result in the Scopus database
2-s2.0-85115041946