Healthy Microbiome – A Mere Idea or a Sound Concept?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565865" target="_blank" >RIV/61388971:_____/22:00565865 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/22:00083548 RIV/00216224:14310/22:00128467
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2022/71_719.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2022/71_719.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934967" target="_blank" >10.33549/physiolres.934967</a>

Result language
angličtina
Original language name
Healthy Microbiome – A Mere Idea or a Sound Concept?
Original language description
Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: “What is the healthy microbiome?” or “Is it possible to define it unequivocally?”. In this review, we describe the main hindrances complicating the definition of “healthy microbiome” in terms of microbiota composition. We discuss the human microbiome from the perspective of classical ecology and we advocate for the shift from the stress on microbiota composition to the functions that microbiome ensures for the host. Finally, we propose to leave thenconcept of ideal healthy microbiome and replace it by focus on microbiome advantageous for the host, which always depends onnthe specific context like the age, genetics, dietary habits, bodynsite or physiological staten n
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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