Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00603817" target="_blank" >RIV/61388971:_____/22:00603817 - isvavai.cz</a>

Result on the web

<a href="https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000890" target="_blank" >https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000890</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1099/mgen.0.000890" target="_blank" >10.1099/mgen.0.000890</a>

Result language

angličtina

Original language name

Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria

Original language description

Gene transfer agents (GTAs) are phage-like particles that transfer pieces of cellular genomic DNA to other cells. Homologues of the Rhodobacter capsulatus GTA (RcGTA) structural genes are widely distributed in the Alphaproteobacteria and particularly well conserved in the order Rhodobacterales. Possible reasons for their widespread conservation are still being discussed. It has been suggested that these alphaproteobacterial elements originate from a prophage that was present in an ancestral bacterium and subsequently evolved into a GTA that is now widely maintained in extant descendant lineages. Here, we analysed genomic properties that might relate to the conservation of these alphaproteobacterial GTAs. This revealed that the chromosomal locations of the GTA gene clusters are biased. They primarily occur on the leading strand of DNA replication, at large distances from long repetitive elements, and thus are in regions of lower plasticity, and in areas of extreme GC skew, which also accumulate core genes. These extreme GC skew regions arise from the preferential use of codons with an excess of G over C, a distinct phenomenon from the elevated GC content that has previously been found to be associated with GTA genes. The observed properties, along with their high level of conservation, show that GTA genes share multiple features with core genes in the examined lineages of the Alphaproteobacteria.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microbial Genomics

ISSN

2057-5858

e-ISSN

2057-5858

Volume of the periodical

8

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

000890

UT code for WoS article

000993252000005

EID of the result in the Scopus database

2-s2.0-85141444284