Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00566813" target="_blank" >RIV/61388971:_____/23:00566813 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10454191 RIV/00216208:11310/23:10454191 RIV/00216208:11110/23:10454191 RIV/00064211:_____/23:W0000034 RIV/00023001:_____/23:00083625
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcimb.2022.1064537/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcimb.2022.1064537/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcimb.2022.1064537" target="_blank" >10.3389/fcimb.2022.1064537</a>

Result language
angličtina
Original language name
Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy
Original language description
Crohn’s disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where the role of gut but not skin dysbiosis is well recognized. Inhibitors of TNF have been successful in IBD treatment, but up to a quarter of patients suffer from unpredictable skin adverse events (SkAE). For this purpose, we analyzed temporal dynamics of skin microbiota and serumnmarkers of inflammation and epithelial barrier integrity during anti-TNF therapy and SkAE manifestation in IBD patients. We observed that the skin microbiota signature of IBD patients differs markedly from healthy subjects. In particular, the skin microbiota of CD patients differs significantly from that of UC patients and healthy subjects, mainly in the retroauricular crease. In addition, we showed that anti-TNF-related SkAE are associated with specific shifts in skin microbiota profile and with a decrease in serum levels of L-FABP and I-FABP innIBD patients. For the first time, we showed that shifts in microbial composition in IBD patients are not limited to the gut and that skin microbiota and serum markers of the epithelium barrier may be suitable markers of SkAE during anti-TNF therapy.n
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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