Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00573084" target="_blank" >RIV/61388971:_____/23:00573084 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10472928 RIV/60461373:22330/23:43927265
Result on the web
<a href="https://www.mdpi.com/1420-3049/28/10/4039" target="_blank" >https://www.mdpi.com/1420-3049/28/10/4039</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules28104039" target="_blank" >10.3390/molecules28104039</a>
Alternative languages
Result language
angličtina
Original language name
Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly
Original language description
Galectins are carbohydrate-binding lectins that modulate the proliferation, apoptosis, adhesion, or migration of cells by cross-linking glycans on cell membranes or extracellular matrix components. Galectin-4 (Gal-4) is a tandem-repeat-type galectin expressed mainly in the epithelial cells of the gastrointestinal tract. It consists of an N- and a C-terminal carbohydrate-binding domain (CRD), each with distinct binding affinities, interconnected with a peptide linker. Compared to other more abundant galectins, the knowledge of the pathophysiology of Gal-4 is sparse. Its altered expression in tumor tissue is associated with, for example, colon, colorectal, and liver cancers, and it increases in tumor progression, and metastasis. There is also very limited information on the preferences of Gal-4 for its carbohydrate ligands, particularly with respect to Gal-4 subunits. Similarly, there is virtually no information on the interaction of Gal-4 with multivalent ligands. This work shows the expression and purification of Gal-4 and its subunits and presents a structure-affinity relationship study with a library of oligosaccharide ligands. Furthermore, the influence of multivalency is demonstrated in the interaction with a model lactosyl-decorated synthetic glycoconjugate. The present data may be used in biomedical research for the design of efficient ligands of Gal-4 with diagnostic or therapeutic potential.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GF22-00197K" target="_blank" >GF22-00197K: Chemo-enzymatic synthesis of selective multivalent neo-glycoproteins for galectin-4 inhibition</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
28
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
4039
UT code for WoS article
000998092900001
EID of the result in the Scopus database
2-s2.0-85160591247