Kingella kingae RtxA toxin interacts with sialylated gangliosides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00575316" target="_blank" >RIV/61388971:_____/23:00575316 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10477272
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0882401023002334?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0882401023002334?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micpath.2023.106200" target="_blank" >10.1016/j.micpath.2023.106200</a>
Alternative languages
Result language
angličtina
Original language name
Kingella kingae RtxA toxin interacts with sialylated gangliosides
Original language description
The membrane-damaging RTX family cytotoxin RtxA is a key virulence factor of the emerging pediatric pathogen Kingella kingae, but little is known about the mechanism of RtxA binding to host cells. While we have previously shown that RtxA binds cell surface glycoproteins, here we demonstrate that the toxin also binds different types of gangliosides. The recognition of gangliosides by RtxA depended on sialic acid side groups of ganglioside glycans. Moreover, binding of RtxA to epithelial cells was significantly decreased in the presence of free sialylated gangliosides, which inhibited cytotoxic activity of the toxin. These results suggest that RtxA utilizes sialylated gangliosides as ubiquitous cell membrane receptor molecules on host cells to exert its cytotoxic action and support K. kingae infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microbial Pathogenesis
ISSN
0882-4010
e-ISSN
1096-1208
Volume of the periodical
181
Issue of the periodical within the volume
AUG
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
106200
UT code for WoS article
001028930200001
EID of the result in the Scopus database
2-s2.0-85161800626