Antibiotic resistance and biofilm-forming ability of a-toxin-positive Clostridium septicum isolates worsen patient prognosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00576018" target="_blank" >RIV/61388971:_____/23:00576018 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10477281

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/apm.13338" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/apm.13338</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/apm.13338" target="_blank" >10.1111/apm.13338</a>

Result language

angličtina

Original language name

Antibiotic resistance and biofilm-forming ability of a-toxin-positive Clostridium septicum isolates worsen patient prognosis

Original language description

A total of, 78 Clostridium septicum (CLSE) isolates were screened for genes encoding: a-toxin, flagellin, and resistance to vancomycin (VANg). The isolates were also tested for their ability to form biofilm and their antibiotic susceptibility. All isolates were positive for a-toxin and flagellin genes. However, only 19 isolates (24.3%) showed prevalence for VANg. We observed the strongest capacity to form a biofilm (100%) in isolates from patients with oncologic or septic and febrile diagnoses. This percentage was also very high in patients with colitis and gastrointestinal hemorrhage (72.7%). No less than 43 isolates showed antibiotic resistance, and 21 were multidrug-resistant (MDR). Interestingly, our studies showed a correlation between antibiotic resistance and biofilm formation. A statistically significant difference was observed between biofilm-forming MDR isolates and those with low/no biofilm-forming ability. However, the most impressive observation was the correlation with mortality rate. While the overall mortality rate for CLSE infections was 16.7% (13/78), the mortality rate for patients infected with MDR isolates forming biofilm moderately or strongly reached 38.1% (8/21). This number increased even further when only infections with the biofilm-forming VANg-positive isolates were considered (61.5%, 8/13). Therefore, the ability of a VANg-positive CLSE isolate to form a biofilm has been suggested as a biomarker of poor prognosis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Pathologica Microbiologica et Immunologica Scandinavica

ISSN

0903-4641

e-ISSN

1600-0463

Volume of the periodical

131

Issue of the periodical within the volume

8

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

434-441

UT code for WoS article

001019829100001

EID of the result in the Scopus database

2-s2.0-85162856576