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[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00578119" target="_blank" >RIV/61388971:_____/23:00578119 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/23:10157991

  • Result on the web

    <a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acs.jmedchem.3c00469" target="_blank" >10.1021/acs.jmedchem.3c00469</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    [68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography

  • Original language description

    Bacteria from the Burkholderia cepacia complex are generally consideredto be non-pathogenic to the healthypopulation. However, some of these species may cause serious nosocomialinfections in immunocompromised patients, as such, it is essentialto diagnose these infections rapidly so that adequate treatment canbe initiated. We report here the use of a radiolabeled siderophore,ornibactin (ORNB), for positron emission tomography imaging. We successfullyradiolabeled ORNB with gallium-68 with high radiochemical purity andproved that the resulting complex has optimal in vitro characteristics. In mice, the complex did not show excessive accumulationin organs and was excreted in the urine. We demonstrated that the[Ga-68]-Ga-ORNB complex accumulates at the site of Burkholderia multivorans infection, including pneumonia,in two animal infection models. These results suggest that [Ga-68]-Ga-ORNB is a promising tool for the diagnosis, monitoring, andevaluation of the therapeutic response to B. cepacia complex infection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Medicinal Chemistry

  • ISSN

    0022-2623

  • e-ISSN

    1520-4804

  • Volume of the periodical

    66

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    7584-7593

  • UT code for WoS article

    001004212000001

  • EID of the result in the Scopus database

    2-s2.0-85163237048