[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00578119" target="_blank" >RIV/61388971:_____/23:00578119 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/23:10157991
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jmedchem.3c00469" target="_blank" >10.1021/acs.jmedchem.3c00469</a>
Alternative languages
Result language
angličtina
Original language name
[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography
Original language description
Bacteria from the Burkholderia cepacia complex are generally consideredto be non-pathogenic to the healthypopulation. However, some of these species may cause serious nosocomialinfections in immunocompromised patients, as such, it is essentialto diagnose these infections rapidly so that adequate treatment canbe initiated. We report here the use of a radiolabeled siderophore,ornibactin (ORNB), for positron emission tomography imaging. We successfullyradiolabeled ORNB with gallium-68 with high radiochemical purity andproved that the resulting complex has optimal in vitro characteristics. In mice, the complex did not show excessive accumulationin organs and was excreted in the urine. We demonstrated that the[Ga-68]-Ga-ORNB complex accumulates at the site of Burkholderia multivorans infection, including pneumonia,in two animal infection models. These results suggest that [Ga-68]-Ga-ORNB is a promising tool for the diagnosis, monitoring, andevaluation of the therapeutic response to B. cepacia complex infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Medicinal Chemistry
ISSN
0022-2623
e-ISSN
1520-4804
Volume of the periodical
66
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
7584-7593
UT code for WoS article
001004212000001
EID of the result in the Scopus database
2-s2.0-85163237048