External Support of Autologous Internal Jugular Vein Grafts with FRAME Mesh in a Porcine Carotid Artery Model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00587360" target="_blank" >RIV/61388971:_____/24:00587360 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/24:00084927 RIV/00216208:11110/24:10481627 RIV/00216208:11120/24:43927291 RIV/00216208:11130/24:10481627 RIV/00064190:_____/24:10001302

Result on the web

<a href="https://www.mdpi.com/2227-9059/12/6/1335" target="_blank" >https://www.mdpi.com/2227-9059/12/6/1335</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biomedicines12061335" target="_blank" >10.3390/biomedicines12061335</a>

Result language

angličtina

Original language name

External Support of Autologous Internal Jugular Vein Grafts with FRAME Mesh in a Porcine Carotid Artery Model

Original language description

Background: Autologous vein grafts are widely used for bypass procedures in cardiovascular surgery. However, these grafts are susceptible to failure due to vein graft disease. Our study aimed to evaluate the impact of the latest-generation FRAME external support on vein graft remodeling in a preclinical model. Methods: We performed autologous internal jugular vein interposition grafting in porcine carotid arteries for one month. Four grafts were supported with a FRAME mesh, while seven unsupported grafts served as controls. The conduits were examined through flowmetry, angiography, macroscopy, and microscopy. Results: The one-month patency rate of FRAME-supported grafts was 100% (4/4), whereas that of unsupported controls was 43% (3/7, Log-rank p = 0.071). On explant angiography, FRAME grafts exhibited significantly more areas with no or mild stenosis (9/12) compared to control grafts (3/21, p = 0.0009). Blood flow at explantation was higher in the FRAME grafts (145 +/- 51 mL/min) than in the controls (46 +/- 85 mL/min, p = 0.066). Area and thickness of neo-intimal hyperplasia (NIH) at proximal anastomoses were similar for the FRAME and the control groups: 5.79 +/- 1.38 versus 6.94 +/- 1.10 mm2, respectively (p = 0.558) and 480 +/- 95 vs. 587 +/- 52 mu m2/mu m, respectively (p = 0.401). However, in the midgraft portions, the NIH area and thickness were significantly lower in the FRAME group than in the control group: 3.73 +/- 0.64 vs. 6.27 +/- 0.64 mm2, respectively (p = 0.022) and 258 +/- 49 vs. 518 +/- 36 mu m2/mu m, respectively (p = 0.0002). Conclusions: In our porcine model, the external mesh FRAME improved the patency of vein-to-carotid artery grafts and protected them from stenosis, particularly in the mid regions. The midgraft neo-intimal hyperplasia was two-fold thinner in the meshed grafts than in the controls.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicines

ISSN

2227-9059

e-ISSN

2227-9059

Volume of the periodical

12

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

28

Pages from-to

1335

UT code for WoS article

001254538900001

EID of the result in the Scopus database

2-s2.0-85197866516