Synergistic Effects of Fructose and Food Preservatives on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): From Gut Microbiome Alterations to Hepatic Gene Expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00601330" target="_blank" >RIV/61388971:_____/24:00601330 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2072-6643/16/21/3722" target="_blank" >https://www.mdpi.com/2072-6643/16/21/3722</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nu16213722" target="_blank" >10.3390/nu16213722</a>
Alternative languages
Result language
angličtina
Original language name
Synergistic Effects of Fructose and Food Preservatives on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): From Gut Microbiome Alterations to Hepatic Gene Expression
Original language description
This study examined how fructose combined with food preservatives affects metabolic dysfunction-associated steatotic liver disease (MASLD) using mice with human microbiota. The research found that fructose with potassium sorbate significantly worsened liver condition, showing increased fat accumulation, inflammation, and scarring. These changes were accompanied by disrupted gut bacteria and fungi populations, compromised intestinal barrier function, and altered gene expression related to metabolism and inflammation. The findings suggest that the combination of fructose and certain preservatives, especially potassium sorbate, may increase MASLD risk through gut microbiome disruption and metabolic changes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrients
ISSN
2072-6643
e-ISSN
2072-6643
Volume of the periodical
16
Issue of the periodical within the volume
21
Country of publishing house
CH - SWITZERLAND
Number of pages
23
Pages from-to
3722
UT code for WoS article
001351828200001
EID of the result in the Scopus database
2-s2.0-85208579698