Pig translational model in immunological research

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00602406" target="_blank" >RIV/61388971:_____/24:00602406 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1456470/full" target="_blank" >https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1456470/full</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Pig translational model in immunological research
Original language description
The pig is, due to its similarity to humans in anatomy, physiology, and genetics, a frequently used translational animal model in biomedical research . Closed composition of human and pig microbiomes predestine the pig to microbiota-host interference studies. Histological differences in human hemochorial and pig epitheliochorial placentas allow modulation of immunocompetence in newborn piglets reared in microbiologically controlled (gnotobiotic) conditions .Progress in xenotransplantation of pig organs to humans underlines the importance of the pig in biomedical research. Therefore, further development and characterization of pig models are required, and new knowledge in this area is welcomed.
Czech name
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Czech description
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Project
<a href="/en/project/GA21-15621S" target="_blank" >GA21-15621S: Defined minimal microbiota in protection against foodborne pathogen Salmonella enterica</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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