Role of IgA1 protease-producing bacteria in SARS-CoV-2 infection and transmission: a hypothesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00602639" target="_blank" >RIV/61388971:_____/24:00602639 - isvavai.cz</a>
Result on the web
<a href="https://journals.asm.org/doi/10.1128/mbio.00833-24" target="_blank" >https://journals.asm.org/doi/10.1128/mbio.00833-24</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/mbio.00833-24" target="_blank" >10.1128/mbio.00833-24</a>
Alternative languages
Result language
angličtina
Original language name
Role of IgA1 protease-producing bacteria in SARS-CoV-2 infection and transmission: a hypothesis
Original language description
Secretory (S) IgA antibodies against severe acute respiratory syndrome (SARS)-CoV-2 are induced in saliva and upper respiratory tract (URT) secretions by natural infection and may be critical in determining the outcome of initial infection. Secretory IgA1 (SIgA1) is the predominant isotype of antibodies in these secretions. Neutralization of SARS-CoV-2 is most effectively accomplished by polymeric antibodies such as SIgA. We hypothesize that cleavage of SIgA1 antibodies against SARS-CoV-2 by unique bacterial IgA1 proteases to univalent Fab alpha antibody fragments with diminished virus neutralizing activity would facilitate the descent of the virus into the lungs to cause serious disease and also enhance its airborne transmission to others. Recent studies of the nasopharyngeal microbiota of patients with SARS-CoV-2 infection have revealed significant increases in the proportions of IgA1 protease-producing bacteria in comparison with healthy subjects. Similar considerations might apply also to other respiratory viral infections including influenza, possibly explaining the original attribution of influenza to Haemophilus influenzae, which produces IgA1 protease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
mBio
ISSN
2150-7511
e-ISSN
2150-7511
Volume of the periodical
15
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
mbio.00833-24
UT code for WoS article
001301049800009
EID of the result in the Scopus database
2-s2.0-85206959310