ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00619782" target="_blank" >RIV/61388971:_____/25:00619782 - isvavai.cz</a>

Alternative codes found

RIV/61389005:_____/25:00619782 RIV/10974938:_____/25:25_87_06

Result on the web

<a href="https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1567622" target="_blank" >https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1567622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphy.2025.1567622" target="_blank" >10.3389/fphy.2025.1567622</a>

Result language

angličtina

Original language name

ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons

Original language description

The ELIMAIA-ELIMED beamline, powered by the L3 HAPLS petawatt laser, enables the irradiation of biological samples with intermediate-energy laser-driven protons (LDP) in a multi-shot regime. In the pilot radiobiological experiment, protons with a mean energy of similar to 24 MeV and doses up to similar to 14 mGy per shot, with similar to 4 ns bunch duration, were used to irradiate AG01522 normal human skin fibroblasts. The shortest irradiation time achieved was down to similar to 17 min/Gy, while the mean and peak dose rates reached similar to 1 x 10-3 and 3.5 x 106 Gy/s, respectively. The cells were exposed to doses ranging from similar to 0.4 to 1.5 Gy and analyzed for DNA damage, with double-strand breaks visualized as 53BP1 foci. Despite the differences in shot exposures between the multi-shot LDP and the previous experiments (at other facility) with single-shot LDP, similar DNA damage responses were observed. Results with conventionally accelerated protons align closely with the corresponding single-shot LDP samples. These experimental results were achieved as part of the flagship experiment FLAIM (within the IMPULSE EU-funded project) and serve as an initial demonstration of the ELIMAIA-ELIMED platform's potential for advanced radiobiological research, creating new opportunities for such studies utilizing laser-driven ion sources.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Physics

ISSN

2296-424X

e-ISSN

2296-424X

Volume of the periodical

13

Issue of the periodical within the volume

April

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

1567622

UT code for WoS article

001481850700001

EID of the result in the Scopus database

2-s2.0-105004417179