Aspergillus latus: A cryptic causative agent of aspergillosis emerging in Japan
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00637068" target="_blank" >RIV/61388971:_____/25:00637068 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10500357
Result on the web
<a href="https://academic.oup.com/mmy/article/63/6/myaf052/8159885?login=true" target="_blank" >https://academic.oup.com/mmy/article/63/6/myaf052/8159885?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mmy/myaf052" target="_blank" >10.1093/mmy/myaf052</a>
Alternative languages
Result language
angličtina
Original language name
Aspergillus latus: A cryptic causative agent of aspergillosis emerging in Japan
Original language description
Allodiploid hybrid species, Aspergillus latus, belonging to section Nidulantes, is a hybrid of A. spinulosporus and an unknown species closely related to A. quadrilineatus and A. sublatus. This hybrid has often been misidentified as the species in section Nidulantes, such as A. nidulans, A. spinulosporus, A. sublatus, or other cryptic species. Aspergillus latus has not been reported in Japan as well as Asia so far. In this study, we screened 23 clinical strains identified as A. spinulosporus isolated in Japan from 2012 to 2023 and found seven A. latus strains. To characterize the A. latus strains, we conducted comprehensive phenotyping including morphological observation, whole genome sequences, and phylogenetic analysis based on calmodulin (CaM) gene. In addition, we conducted antifungal susceptibility testing for A. latus strains. As a result, the morphological characters of A. latus were more similar to those of A. spinulosporus compared to A. sublatus. However, the ascospore of A. latus differed from that of A. spinulosporus. Phylogenetic analysis revealed that different CaM alleles from the same isolate clustered separately with A. spinulosporus and A. sublatus, consistent with its hybrid origin. Furthermore, A. latus strains showed reduced susceptibility to caspofungin and amphotericin B compared to A. spinulosporus, while they were susceptible to azoles. Our results suggest that A. latus has been a causative pathogen of aspergillosis in Japan since 2013.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical Mycology
ISSN
1369-3786
e-ISSN
1460-2709
Volume of the periodical
63
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
myaf052
UT code for WoS article
001514432500001
EID of the result in the Scopus database
2-s2.0-105009847041