Cell differentiation, aging, and death in spatially organized yeast communities: mechanisms and consequences

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00640233" target="_blank" >RIV/61388971:_____/25:00640233 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/25:10499627

Result on the web

<a href="https://www.nature.com/articles/s41418-025-01485-9" target="_blank" >https://www.nature.com/articles/s41418-025-01485-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41418-025-01485-9" target="_blank" >10.1038/s41418-025-01485-9</a>

Result language

angličtina

Original language name

Cell differentiation, aging, and death in spatially organized yeast communities: mechanisms and consequences

Original language description

Cell death is a natural part of the development of multicellular organisms and is central to their physiological and pathological states. However, the existence of regulated cell death in unicellular microorganisms, including eukaryotic and prokaryotic microbes, has been a topic of debate. One reason for the continued debate is the lack of obvious benefit from cell death in the context of a single cell. However, unicellularity is relative, as most of these microbes dwell in communities of varying complexities, often with complicated spatial organization. In these spatially organized microbial communities, such as yeast and bacterial colonies and biofilms growing on solid surfaces, cells differentiate into specialized types, and the whole community often behaves like a simple multicellular organism. As these communities develop and age, cell death appears to offer benefits to the community as a whole. This review explores the potential roles of cell death in spatially organized communities of yeasts and draws analogies to similar communities of bacteria. The natural dying processes in microbial cell communities are only partially understood and may result from suicidal death genes, (self-)sabotage (without death effectors), or from non-autonomous mechanisms driven by interactions with other differentiated cells. We focus on processes occurring during the stratification of yeast colonies, the formation of the extracellular matrix in biofilms, and discuss potential roles of cell death in shaping the organization, differentiation, and overall physiology of these microbial structures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Death and Differentiation

ISSN

1350-9047

e-ISSN

1476-5403

Volume of the periodical

32

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

1557-1569

UT code for WoS article

001454839800001

EID of the result in the Scopus database

2-s2.0-105001489572