Microbiome and metabolic disruption in acute vs. severe and enduring anorexia nervosa

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00642748" target="_blank" >RIV/61388971:_____/25:00642748 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10506008 RIV/00216208:11310/25:10506008 RIV/00064165:_____/25:10506008

Result on the web

<a href="https://www.nature.com/articles/s41522-025-00847-y" target="_blank" >https://www.nature.com/articles/s41522-025-00847-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41522-025-00847-y" target="_blank" >10.1038/s41522-025-00847-y</a>

Result language

angličtina

Original language name

Microbiome and metabolic disruption in acute vs. severe and enduring anorexia nervosa

Original language description

Anorexia nervosa (AN) is associated with profound alterations in gut microbiota and host metabolic profiles. While previous studies have primarily focused on the acute phase of AN, the chronic form, severe and enduring anorexia nervosa (SEAN), remains underexplored in terms of microbiome dynamics. In this study, we characterized gut microbiota composition (via 16S rRNA gene amplicon sequencing), serum and fecal metabolites (via mass spectrometry), and an extensive range of clinical, anthropometric, biochemical, and psychiatric parameters in females with acute AN, SEAN, and in healthy controls. SEAN patients exhibited higher antidepressant usage and greater lifetime stress exposure. Acute AN patients presented with more pronounced eating disorder severity and depressive symptoms. Elevated levels of intestinal fatty acid-binding protein in SEAN patients suggest mucosal damage. Microbiota analysis revealed reduced alpha diversity and distinct community composition in both AN groups, with SEAN showing the greatest interindividual variability. Both AN cohorts exhibited significantly lower serum and fecal gamma-aminobutyric acid (GABA) levels, which were negatively correlated with taxa such as Christensenellaceae, Ruminococcaceae, and Escherichia-Shigella, i.e., microorganisms potentially associated with GABA degradation or impaired synthesis. Additionally, reductions in short-chain fatty acids suggest impaired microbial fermentation and dysregulation of the gut-brain axis. Collectively, these findings reveal progressive, functionally relevant changes in microbiota-host interactions in SEAN. These alterations likely reflect the persistent disease state and may contribute to its continuation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

npj Biofilms and Microbiomes

ISSN

2055-5008

e-ISSN

2055-5008

Volume of the periodical

11

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

217

UT code for WoS article

001624979300004

EID of the result in the Scopus database

2-s2.0-105023159634