New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F11%3A00358366" target="_blank" >RIV/61388980:_____/11:00358366 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/11:00009171
Result on the web
<a href="http://dx.doi.org/10.1097/CAD.0b013e328341a17b" target="_blank" >http://dx.doi.org/10.1097/CAD.0b013e328341a17b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/CAD.0b013e328341a17b" target="_blank" >10.1097/CAD.0b013e328341a17b</a>
Alternative languages
Result language
angličtina
Original language name
New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals
Original language description
Doxorubicin belongs to anthracycline cytotoxic drugs and it is widely used as a major therapeutic agent in the treatment of various types of tumors. However, its therapeutic use is limited by the development of myelosuppression and cardiotoxicity after aspecific cumulative dose is reached. The aim of this study was to investigate the effect of flavonoids, either natural or synthetic on doxorubicin-mediated formation of oxidative stress implicated in doxorubicin toxicity. Doxorubicin caused a concentration-dependent increase in the formation of hydroxyl radicals in minipig liver microsomes used as an in-vitro model system. When bacterial membranes heterologously expressing human NADPH cytochrome-P450 oxidoreductase were incubated with doxorubicin, formation of the superoxide radical under aerobic conditions and the doxorubicin-semiquinone radical under anaerobic conditions was detected.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anti-cancer Drugs
ISSN
0959-4973
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
176-184
UT code for WoS article
000285545200007
EID of the result in the Scopus database
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