A new possible way of anthracycline cytostatics decontamination
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F17%3A00475066" target="_blank" >RIV/61388980:_____/17:00475066 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/17:00475066 RIV/00216208:11110/17:10363933
Result on the web
<a href="http://dx.doi.org/10.1039/c6nj03051c" target="_blank" >http://dx.doi.org/10.1039/c6nj03051c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c6nj03051c" target="_blank" >10.1039/c6nj03051c</a>
Alternative languages
Result language
angličtina
Original language name
A new possible way of anthracycline cytostatics decontamination
Original language description
The widespread use of cytotoxic drugs in the treatment of cancer has led to the production of large amounts of contaminated wastes with high exposure risk of medical staff handling cytostatics. For this reason it is essential to use a highly effective and fast decontaminating agent for the decontamination process. Currently used decontamination agents based on NaOCl and NaOH are not sufficient according to our results and also according to literature data. Therefore we have developed a new decontamination agent based on titania nanoparticles, which appears to be a very efficient and fast decontamination agent according to our research data. Anthracycline antibiotics are valuable and frequently used drugs in various chemotherapeutic schemes. They have high efficacy, but also high toxicity, e.g. myelosuppression and cardiotoxicity. They can also act as vesicants in the case of extravasation. Due to their mechanism of action, anthracycline antibiotics have mutagenic and carcinogenic effects. Long term contact, even with a trace amount, can cause changes in human health. Safe decontamination of cytotoxic drug contaminated areas with an agent, which can cause degradation to non-toxic products, is essential. High sorption ability of doxorubicin and epirubicin to titania predisposes TiO2 to become a new, effective and inexpensive agent for area decontamination and degradation of anthracycline antibiotics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
New Journal of Chemistry
ISSN
1144-0546
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
3975-3985
UT code for WoS article
000401533200033
EID of the result in the Scopus database
2-s2.0-85022092526