Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00503776" target="_blank" >RIV/61388980:_____/18:00503776 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis
Original language description
Nosocomial infections are often caused by bacteria from the Staphylococcus genus. The clinically relevant representatives of this species are Staphylococcus epidermidis and Staphylococcus aureus which grow predominantly as surface-attached stable communities known as biofilms. Cells in these biofilms are often highly resistant to antibiotics. Therefore, new antimicrobial or antibiofilm substances are still being developed. In this study, we investigated the influence of cobalt bis(dicarbollide) or its amino derivatives, and antibiotics (erythromycin, tetracycline)-alone and in combination-to determine the antimicrobial activity and the inhibition of biofilm formation against three type strains of S. epidermidis. We used a microcultivation device to determine the minimum inhibitory concentrations and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the metabolic activity of the cells in biofilms. We observed the synergistic effect of cobalt bis(dicarbollide) and its amino derivatives with both the antibiotics on both the planktonic and biofilm cells.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 6th International Conference on Chemical Technology
ISBN
978-80-86238-77-7
ISSN
2336-8128
e-ISSN
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Number of pages
4
Pages from-to
91-94
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Mikulov
Event date
Apr 16, 2018
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000461293800018

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