How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F22%3A00560142" target="_blank" >RIV/61388980:_____/22:00560142 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13440/22:43897019 RIV/44555601:13520/22:43897019 RIV/29372259:_____/22:N0000027
Result on the web
<a href="https://doi.org/10.1039/D2EN00173J" target="_blank" >https://doi.org/10.1039/D2EN00173J</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2en00173j" target="_blank" >10.1039/d2en00173j</a>

Result language
angličtina
Original language name
How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity
Original language description
Five different water-based precipitation methods have been used to prepare nanoceria with significantly different redox and acid/base properties, which have been described in detail by a number of analytical methods. Differences in particle size, morphology, porosity, but especially in defect structure and in the surface chemical composition of nanoceria had a crucial impact on their reactivity in several environmentally and biologically oriented model reactions. Ceria-catalyzed hydrolysis of two phosphodiester biomolecules (p-NPPC and p-NP-TMP) revealed high phospholipase C and D mimetic activity of all tested materials. On the other hand, the efficiency in degradation of toxic organophosphates (methyl parathion/oxon, agent VX, GD) is highly dependent on the solvent used (water or acetonitrile). Water slows down the degradation rate, but has a strikingly different effect on each ceria sample, which is related to the ceria surface structure and its interaction with the model compound and/or water. Two materials with a significant number of defects and oxygen-containing surface groups also showed highly virucidal properties against enveloped (adenovirus 5) and non-enveloped (human herpes simplex) viruses while having very low cytotoxicity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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