Size and Polarizability of Boron Cluster Carriers Modulate Chaotropic Membrane Transport
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F24%3A00587116" target="_blank" >RIV/61388980:_____/24:00587116 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0354847" target="_blank" >https://hdl.handle.net/11104/0354847</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.202404286" target="_blank" >10.1002/anie.202404286</a>
Alternative languages
Result language
angličtina
Original language name
Size and Polarizability of Boron Cluster Carriers Modulate Chaotropic Membrane Transport
Original language description
Perhalogenated closo-borates represent a new class of membrane carriers. They owe this activity to their chaotropicity, which enables the transport of hydrophilic molecules across model membranes and into living cells. The transport efficiency of this new class of cluster carriers depends on a careful balance between their affinity to membranes and cargo, which varies with chaotropicity. However, the structure–activity parameters that define chaotropic transport remain to be elucidated. Here, we have studied the modulation of chaotropic transport by decoupling the halogen composition from the boron core size. The binding affinity between perhalogenated decaborate and dodecaborate clusters carriers was quantified with different hydrophilic model cargos, namely a neutral and a cationic peptide, phalloidin and (KLAKLAK)2. The transport efficiency, membrane-lytic properties, and cellular toxicity, as obtained from different vesicle and cell assays, increased with the size and polarizability of the clusters. These results validate the chaotropic effect as the driving force behind the membrane transport propensity of boron clusters. This work advances our understanding of the structural features of boron cluster carriers and establishes the first set of rational design principles for chaotropic membrane transporters.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA21-14409S" target="_blank" >GA21-14409S: Exopolyhedral substitutions at metallacarborane cages and their stereochemistry</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
1521-3773
Volume of the periodical
63
Issue of the periodical within the volume
29
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
e202404286
UT code for WoS article
001246125100001
EID of the result in the Scopus database
2-s2.0-85195832801