Antifungal Associations with a Polyelectrolyte Promote Significant Reduction of Minimum Inhibitory Concentrations against Opportunistic Candida spp. Strains

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F24%3A00601027" target="_blank" >RIV/61388980:_____/24:00601027 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/24:10497385

Result on the web

<a href="https://doi.org/10.1007/s00284-024-03960-x" target="_blank" >https://doi.org/10.1007/s00284-024-03960-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00284-024-03960-x" target="_blank" >10.1007/s00284-024-03960-x</a>

Result language

angličtina

Original language name

Antifungal Associations with a Polyelectrolyte Promote Significant Reduction of Minimum Inhibitory Concentrations against Opportunistic Candida spp. Strains

Original language description

The current global scenario presents us with a growing increase in infections caused by fungi, referred to by specialists in the field as a “silent epidemic”, aggravated by the limited pharmacological arsenal and increasing resistance to this therapy. For this reason, drug repositioning and therapeutic compound combinations are promising strategies to mitigate this serious problem. In this context, this study investigates the antifungal activity of the non-toxic, low-cost and widely available cationic polyelectrolyte Poly(diallyldimethylammonium chloride) (PDDA), in combination with different antifungal drugs: systemic (amphotericin B, AMB), topical (clioquinol, CLIO) and oral (nitroxoline, NTX). For each combination, different drug:PDDA ratios were tested and, through the broth microdilution technique, the minimum inhibitory concentration (MIC) of these drugs in the different ratios against clinically important Candida species strains was determined. Overall, PDDA combinations with the studied drugs demonstrated a significant increase in drug activity against most strains, reaching MIC reductions of up to 512 fold for the fluconazole resistant Candida krusei (Pichia kudriavzevii). In particular, the AMB-PDDA combination 1:99 was highly effective against AMB-resistant strains, demonstrating the excellent profile of PDDA as an adjuvant/association in novel antifungal formulations with outdated conventional drugs.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Microbiology

ISSN

0343-8651

e-ISSN

1432-0991

Volume of the periodical

81

Issue of the periodical within the volume

12

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

441

UT code for WoS article

001348658500003

EID of the result in the Scopus database

2-s2.0-85208496419