Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F08%3A00087225" target="_blank" >RIV/61388998:_____/08:00087225 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3

Original language description

In LQT3 patients, SCN5A mutations induce ultraslow inactivation of a small fraction of the hNav1.5 current, i.e. persistent Na+ current (IpNa). We explored the time course of effects of such a change on the intracellular ionic homeostasis in a model of guinea-pig cardiac ventricular cell [Pasek, M., Simurda, J., Orchard, C.H., Christe´ , G., 2007b. A model of the guinea-pig ventricular cardiomyocyte incorporating a transverse?axial tubular system. Prog. Biophys. Mol. Biol., this issue]. Sudden additionof IpNa prevented action potential (AP) repolarization when its conductance (gpNa) exceeded 0.12% of the maximal conductance of fast INa (gNa). With gpNa at 0.1% gNa, the AP duration at 90% repolarization (APD90) was initially lengthened to 2.6-fold thatin control. Under regular stimulation at 1Hz it shortened progressively to 1.37-fold control APD90, and intracellular [Na+]i increased by 6% with a time constant of 106 s.

Czech name

Změny akčního napětí a intracelulární iontové homeostázy vyvolané perzistentním sodíkovým proudem u modelu komorové buňky při SCN5A mutaci podmiňující LQT3

Czech description

Předmětem práce je vyšetření fyziologických důsledků SCN5A mutace sodíkového kanálu u srdečních komorových buněk pomoci matematického modelu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Biophysics & Molecular Biology

ISSN

0079-6107

e-ISSN

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Volume of the periodical

96

Issue of the periodical within the volume

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Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

281-293

UT code for WoS article

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EID of the result in the Scopus database

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