Closo-dodecaborate (2-) anion as a potential prosthetic group for attachment of astatine to proteins. Aspects of the labelling chemistry with Chloramine-T.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F00%3A49033164" target="_blank" >RIV/61389005:_____/00:49033164 - isvavai.cz</a>
Alternative codes found
RIV/61389005:_____/00:00185835
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Closo-dodecaborate (2-) anion as a potential prosthetic group for attachment of astatine to proteins. Aspects of the labelling chemistry with Chloramine-T.
Original language description
Closo-dodecaborate (2-) was proposed as a prosthetic group for direct labelling of proteins with At-211 for radionuclide therapy. Astatination of closo-dodecaborate (2-) anion using Chloramine-T was studied, and the influence of pH, reaction time, amountof substrate and oxidant was determined. A maximum labelling yield of 55 - 75% was found in the pH range 7-8. A spontaneous astatination of closo-dodecaborate (2-) in the absence of Chloramine-T was also found, presumably due to generation of oxidisingproducts from water radiolysis. Our results of indicate that derivatives of closo-dodecaborate (2-) anion may be used as prosthetic groups for direct labelling of proteins.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CH - Nuclear and quantum chemistry, photo chemistry
OECD FORD branch
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Project
<a href="/en/project/KSK4055109" target="_blank" >KSK4055109: Physics, chemistry and informatics for biological, ecological and medicinal applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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