Study of gold nanoparticles for mammography diagnostic and radiotherapy improvements

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00508934" target="_blank" >RIV/61389005:_____/19:00508934 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.rpor.2019.07.005" target="_blank" >https://doi.org/10.1016/j.rpor.2019.07.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rpor.2019.07.005" target="_blank" >10.1016/j.rpor.2019.07.005</a>

Result language

angličtina

Original language name

Study of gold nanoparticles for mammography diagnostic and radiotherapy improvements

Original language description

Aim: A study on the possibility to use gold nanoparticles in mammography, both for a better image diagnostics and radiotherapy, is presented and discussed. We evaluate quantitatively the increment of dose released to the tumor enriched with Au-NPs with respect to the near healthy tissues, finding that for X-rays the increase can reach two orders of greater intensity.nnBackground: Gold nanoparticles continue to be investigated for their potential to improve existing therapies and to develop novel therapies. They are simple to obtain, can be functionalized with different chemical approaches, are stable, non-toxic, non-immunogenic and have high permeability and retention effects in the tumor cells. The possibility to use these for breast calcified tumors to be better treated by radiotherapy is presented as a possible method to destroy the tumor.nnMaterials and methods: The nanoparticles can be generated in water using the top-down method, should have a size of the order of 10-20 nm and be treated to avoid their coalescence. Under diagnostic X-ray monitoring, the solution containing nanoparticles can be injected locally inside the tumor site avoiding injection in healthy tissues. The concentrations that can be used should be of the order of 10 mg/ml or higher.nnResults: An enhancement of the computerized tomography diagnostics using 80-150 key energy is expected, due to the higher mass X-ray coefficient attenuation with respect to other contrast media. Due to the increment of the effective atomic number of the biological tissue containing the gold nanoparticles, also an improvement of the radiotherapy effect using about 30 keV X-ray energy is expected, due to the higher photoelectric cross sections involved.nnConclusions: The study carried out represents a feasibility proposal for the use of Aunanoparticles for mammographic molecular imaging aimed at radiotherapy of tumor nodules but no clinical results are presented.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Reports of Practical Oncology and Radiotherapy.

ISSN

1507-1367

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

5

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

450-457

UT code for WoS article

000485766400006

EID of the result in the Scopus database

2-s2.0-85069869907