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Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00518413" target="_blank" >RIV/61389005:_____/19:00518413 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1007/s13404-019-00266-w" target="_blank" >https://doi.org/10.1007/s13404-019-00266-w</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s13404-019-00266-w" target="_blank" >10.1007/s13404-019-00266-w</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications

  • Original language description

    This work introduces an innovative new method to transport gold nanoparticles (Au-NPs) toward specific organs using as transporter the M13 filamentous phage. The aim is to improve the radiotherapy efficiency by injecting gold nanoparticles in the tumor tissues in order to increase the effective atomic number and, consequently, to produce higher locally deposited doses. The biocompatible Au-NPs can be bonded to the phage surface for their transport in the biological fluids and tissues. M13 phages can be prepared to arrive in specific tissues and organs depending on their biochemical preparation and functionalization. Evidence about the real attachment of spherical Au-NPs, 10 nm in diameter, to the M13 phages is obtained using different microscopies. Other analyses have been also performed to evaluate the number of gold nanoparticles that can be transported by M13 phages inside the organism. Our results on the study of the spherical Au-NP size distribution, deduced by AFM, EFM, and TEM analyses, have indicated that in average, 2 couples of Au-NPs are attached to each phage. Moreover, the size of the NPs ranges between 10 and 30 nm, demonstrating a little aggregation of the nanoparticles, which remain usefully sized to be vehicled with the blood flux towards specific organs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    21001 - Nano-materials (production and properties)

Result continuities

  • Project

    <a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Gold Bulletin

  • ISSN

    2364-821X

  • e-ISSN

    2190-7579

  • Volume of the periodical

    52

  • Issue of the periodical within the volume

    3-4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    135-144

  • UT code for WoS article

    000500786900003

  • EID of the result in the Scopus database

    2-s2.0-85075245198