Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00518413" target="_blank" >RIV/61389005:_____/19:00518413 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s13404-019-00266-w" target="_blank" >https://doi.org/10.1007/s13404-019-00266-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13404-019-00266-w" target="_blank" >10.1007/s13404-019-00266-w</a>
Alternative languages
Result language
angličtina
Original language name
Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications
Original language description
This work introduces an innovative new method to transport gold nanoparticles (Au-NPs) toward specific organs using as transporter the M13 filamentous phage. The aim is to improve the radiotherapy efficiency by injecting gold nanoparticles in the tumor tissues in order to increase the effective atomic number and, consequently, to produce higher locally deposited doses. The biocompatible Au-NPs can be bonded to the phage surface for their transport in the biological fluids and tissues. M13 phages can be prepared to arrive in specific tissues and organs depending on their biochemical preparation and functionalization. Evidence about the real attachment of spherical Au-NPs, 10 nm in diameter, to the M13 phages is obtained using different microscopies. Other analyses have been also performed to evaluate the number of gold nanoparticles that can be transported by M13 phages inside the organism. Our results on the study of the spherical Au-NP size distribution, deduced by AFM, EFM, and TEM analyses, have indicated that in average, 2 couples of Au-NPs are attached to each phage. Moreover, the size of the NPs ranges between 10 and 30 nm, demonstrating a little aggregation of the nanoparticles, which remain usefully sized to be vehicled with the blood flux towards specific organs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gold Bulletin
ISSN
2364-821X
e-ISSN
2190-7579
Volume of the periodical
52
Issue of the periodical within the volume
3-4
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
135-144
UT code for WoS article
000500786900003
EID of the result in the Scopus database
2-s2.0-85075245198