Biocompatible Delivery System for Metformin: Characterization, Radiolabeling and In Vitro Studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F20%3A00534009" target="_blank" >RIV/61389005:_____/20:00534009 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.2174/1871520620666200423081235" target="_blank" >https://doi.org/10.2174/1871520620666200423081235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1871520620666200423081235" target="_blank" >10.2174/1871520620666200423081235</a>
Alternative languages
Result language
angličtina
Original language name
Biocompatible Delivery System for Metformin: Characterization, Radiolabeling and In Vitro Studies
Original language description
Background: In recent years, the uses of nanotechnology in medicine have an increasing potential as an effective nanocarrier system. These systems are improved with the purpose of maximizing therapeutic activity and minimizing undesirable side-effects. Moreover, radiolabeled nanoparticles can be used as agents for diagnosis and therapeutic purposes in clinical applications. They have three main components: the core, the targeting biomolecule, and the radionuclide.nnObjective: It is aimed to synthesize Metformin (MET) loaded Solid Lipid Nanoparticles (MET-SLN) and radiolabeled with technetium-99m tricarbonyl core.nnMethods: The structure of synthesized nanoparticles was characterized by Fourier Transform Infrared Spectroscopy (FTIR). The particle size and morphology of nanoparticles were examined by Dynamic Light Scattering (DLS), and Scanning Electron Microscope (SEM). Quality control studies of radiolabeled MET-SLN [Tc-99m(CO)(3)-MET-SLN] were performed by High-Performance Liquid Radiochromatography (HPLRC) and Thin Layer Radiochromatography (TLRC).nnResults: The radiolabeling yield of [Tc-99m(CO)(3)-MET-SLN] was found to be 88%. In vitro studies have been performed on cancer lines(MCF7, MDA-MD-231 breast, and HEPG2 liver cancer cells) to determine the biological behavior of Tc-99m(CO)3-MET-SLNs.nnConclusion: The results showed that higher uptake values were observed on estrogen-positive MCF7 breast cancer cell line according to estrogen negative MDA-MB-231 breast cancer and HEPG2 liver cancer cell lines.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anti-Cancer Agents in Medicinal Chemistry
ISSN
1871-5206
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
13
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
9
Pages from-to
1626-1634
UT code for WoS article
000573095600002
EID of the result in the Scopus database
2-s2.0-85088953120